IVD reagent material Ka hōʻailona Cardiac

ʻO Cardiac Troponin I (cTnI) kahi ʻano subtype o ka ʻohana troponin i hoʻohana mau ʻia ma ke ʻano he hōʻailona no ka pōʻino myocardial.He kiko'ī ka cardiac troponin I no ka ʻiʻo puʻuwai a ʻike ʻia i loko o ka serum inā ua loaʻa ka ʻeha myocardial.No ka mea, ʻo ka troponin I puʻuwai he hōʻailona koʻikoʻi a kikoʻī o ka pōʻino o ka ʻiʻo puʻuwai (myocardium), hiki ke hoʻohana ʻia nā pae serum e kōkua i ka hoʻokaʻawale ʻana ma waena o ka angina paʻa ʻole a me ka myocardial infarction (ka puʻuwai puʻuwai) i ka poʻe me ka ʻeha o ka umauma a i ʻole ka maʻi coronary acute.

Hoʻohana nui ʻia ka isoform cardiac o TnT ma ke ʻano he hōʻailona o ka hōʻeha o ka myocardial cell, e like me cTnI.Loaʻa i ka cTnT nā kinetics hoʻokuʻu like i loko o ke kahe koko a me ka naʻau like no ka ʻeha myocardial liʻiliʻi e like me cTnI.I loko o ke koko o nā maʻi o ka myocardial infarction (AMI), ʻike pinepine ʻia ka cTnT ma kahi ʻano manuahi a ʻo ka cTnI ka hapa nui o ka paʻakikī me TnC.

ʻO Troponin C, ʻike ʻia hoʻi ʻo TN-C a i ʻole TnC, he pūmua e noho ana i loko o ka troponin complex ma nā filament lahilahi actin o ka ʻiʻo striated (cardiac, fast-twitch skeletal, a i ʻole skeletal slow-twitch) a nona ke kuleana no ka hoʻopaʻa ʻana i ka calcium e hoʻōla. ʻoki ʻiʻo.Hoʻopili ʻia ʻo Troponin C e ka TNNC1 gene i loko o ke kanaka no ka puʻuwai a me ka ʻiʻo skeletal lohi.

ʻO ka myoglobin he protein cytoplasmic e hoʻopaʻa i ka oxygen ma kahi hui heme.Hoʻokahi wale nō pūʻulu globulin, ʻo ka hemoglobin he ʻehā.ʻOiai ua like kona pūʻulu heme me nā mea i loko o Hb, ʻoi aku ka nui o ka pilina o Mb no ka oxygen ma mua o ka hemoglobin.Pili kēia ʻokoʻa i kāna hana ʻokoʻa: ʻoiai ka hemoglobin lawe i ka oxygen, ʻo ka hana a myoglobin ka mālama ʻana i ka oxygen.

Hoʻohana ʻia ʻo Digoxin e mālama i ka hōʻino ʻole o ka naʻau, maʻamau me nā lāʻau lapaʻau ʻē aʻe.Hoʻohana pū ʻia ia e mālama i kekahi ʻano o ka puʻuwai maʻamau (e like me ka fibrillation atrial mau).Hiki ke kōkua i ka mālama ʻana i kou hiki ke hele a hoʻoikaika kino a hoʻomaikaʻi paha i ka ikaika o kou puʻuwai.ʻO ka mālama ʻana i ka puʻuwai maʻamau hiki ke hoʻomaikaʻi i kou hiki ke hoʻoikaika kino. Aia ʻo Digoxin i kahi papa o nā lāʻau i kapa ʻia ʻo cardiac glycosides.Hana ia ma ka hoʻopili ʻana i kekahi mau minela (sodium a me ka potassium) i loko o nā puʻuwai puʻuwai.Hoʻemi kēia i ke kaumaha o ka puʻuwai a kōkua iā ia e mālama i ka puʻuwai maʻamau, paʻa, a ikaika hoʻi.

ʻO CK-MB i loko o ka myocardial infarction (AMI), a me CK-BB i ka pōʻino lolo a me ka maʻi maʻi maʻi o ka ʻāpana gastro-intestinal.Ua ana ʻia ʻo CK-MB ma ka hana enzyme a i ʻole ka ʻike nui a ua ana ʻia ma ke ʻano he hōʻailona ʻaʻole wale i ka ʻike ʻana o AMI akā i ka AMI i manaʻo ʻia a me ka angina paʻa ʻole.

ʻO ka puʻuwai-ʻano-Fatty-Acid-Binding-Protein (hFABP) he protein, kahi i komo i ka lawe ʻana i ka myocardial intracellular (Bruins Slot et al., 2010; Reiter et al., 2013).Ma hope o ka myocardial necrosis ua hoʻokuʻu koke ʻia ka hFABP i ke kahe koko a no laila ua noiʻi ʻia ma ke ʻano he biomarker no AMI.Eia naʻe, ma muli o ka haʻahaʻa haʻahaʻa a me ka kikoʻī ʻaʻole i hōʻoia ʻia ka pono o ka hFABP, ke hoʻohālikelike ʻia i ka hana diagnostic o hs-Tn assays (Bruins Slot et al., 2010; Reiter et al., 2013).

Lipoprotein-Phospholipase A2(Lp-PLA2)

He mau momona ka lipid i kou koko.ʻO nā lipoproteins ka hui pū ʻana o nā momona a me nā protein e lawe i nā momona i loko o kou kahe koko.Inā loaʻa iā ʻoe ka Lp-PLA2 i loko o kou koko, loaʻa paha iā ʻoe nā waihona momona i loko o kou mau aʻa e pilikia ana i ka nahae ʻana a me ka maʻi puʻuwai a i ʻole ka hahau ʻana.

ʻO D-dimer (a i ʻole D dimer) he huahana hoʻohaʻahaʻa fibrin (a i ʻole FDP), kahi ʻāpana protein liʻiliʻi i loaʻa i loko o ke koko ma hope o ka hoʻohaʻahaʻa ʻia ʻana o ke koko e ka fibrinolysis.Kapa ʻia ia no ka loaʻa ʻana o ʻelua mau ʻāpana D o ka protein fibrin i hui pū ʻia me kahi loulou keʻa.